A hydrochlorothiazide-imprinted polymer

被引：11

作者：

Chen, W ^{[1
]}

Liu, F ^{[1
]}

Li, KA ^{[1
]}

Yang, YH ^{[1
]}

Tong, SY ^{[1
]}

机构：

[1] Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

ANALYTICAL LETTERS | 2000年 / 33卷 / 05期

关键词：

hydrochlorothiazide; molecular imprinting; sulfonamide; HCT; BFT; 4-vinylpyridine;

D O I：

10.1080/00032710008543090

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Hydrochlorothiazide (HCT) is a medicine commonly used as a diuretic. A series of HCT-imprinted polymers were prepared using 4-vinylpyridine or methacrylic acid or none as a functional monomer. Liquid chromatographic analysis using the polymers as a stationary phase showed that 4-vinylpyridine was suitable for synthesizing HCT-selective polymers. It appeared that the sulfonamide groups on HCT molecule could interact with 4-vinylpyridine through ionic interaction, and thus could be used as a functional group for molecular imprinting. The prepared HCT-specific polymers should have applications for clinical analysis of HCT.

引用

页码：809 / 818

页数：10