Expression of the proteoglycan SPOCK during mouse embryo development

被引：23

作者：

Charbonnier, F

Chanoine, C

Cifuentes-Diaz, C

Gallien, CL

Rieger, F

Alliel, PM

Périn, JP

机构：

[1] INSERM, IFM, Lab Neuromodulat Interact & Neuropathol, F-75005 Paris, France

[2] Univ Paris 05, Dev Biol Lab, Paris, France

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 90卷 / 02期

关键词：

testican; proteoglycan; mouse; central nervous system; peripheral nervous system; spinal cord; dorsal root ganglia; in situ hybridization; immunohistochemistry; neuron; chondroitin; heparan; SPOCK;

D O I：

10.1016/S0925-4773(99)00255-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SPOCK is a modular proteoglycan, with homology with proteins involved in cell adhesion processes and neurogenesis. We have previously shown that SPOCK transcripts predominate in the adult mouse brain. Here, we report its expression during mouse embryonic development by in situ hybridization, and immunocytochemistry. SPOCK is actively expressed at the onset of neurogenesis during periods of neuron migration and axonal outgrowth. At a later developmental stage, its expression is particularly prevalent within developing synaptic fields. In the peripheral nervous system, SPOCK expression is also developmentally regulated particularly in dorsal root ganglion neurons. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：317 / 321

页数：5