Notch signaling in development and disease

被引：204

作者：

Hansson, EM ^{[1
]}

Lendahl, U ^{[1
]}

Chapman, G ^{[1
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 05期

基金：

英国医学研究理事会;

关键词：

cell-cell communication; endocytosis; CSL; numb; BMP;

D O I：

10.1016/j.semcancer.2004.04.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cells in multicellular organisms need to decipher extracellular cues into appropriate responses including correct differentiation choices. A considerable portion of this information is relayed through a surprisingly small number of signaling pathways, which are highly evolutionarily conserved and used in many different cell types. This "ivy league" of signaling mechanisms comprises the Wnt/wingless, BMP/TGF-beta, Sonic Hedgehog, receptor tyrosine kinases, nuclear receptors, JAK/STAT and, the subject of this review, the Notch signaling pathway. The aim of this article is to provide an overview of the Notch signaling pathway. The role of Notch in various types of cancers is discussed in the accompanying articles in this issue of SCBI. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：320 / 328

页数：9

共 110 条

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