Neuroglobin: A respiratory protein of the nervous system

被引：118

作者：

Burmester, T ^{[1
]}

Hankeln, T

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Zool, D-55099 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Inst Genet Mol, D-55099 Mainz, Germany

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2004年 / 19卷

关键词：

D O I：

10.1152/nips.01513.2003

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Nerve tissues exhibit some of the highest oxygen consumption rates found in the body. Neuroglobin, a heme protein distantly related to hemoglobin, is thought to enhance the supply of oxygen to the neurons, the eye, and some endocrine tissues. Neuroglobin may promote neuronal survival under hypoxic conditions as they occur, for example, in stroke.

引用

收藏

页码：110 / 113

页数：4

相关论文

共 19 条

[11] How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina [J].

Schmidt, M ;

Giessl, A ;

Laufs, T ;

Hankeln, T ;

Wolfrum, U ;

Burmester, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) :1932-1935

[12] Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia [J].

Schmidt, M ;

Gerlach, F ;

Avivi, A ;

Laufs, T ;

Wystub, S ;

Simpson, JC ;

Nevo, E ;

Saaler-Reinhardt, S ;

Reuss, S ;

Hankeln, T ;

Burmester, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (09) :8063-8069

[13] Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury [J].

Sun, YJ ;

Jin, KL ;

Mao, XO ;

Zhu, YH ;

Greenberg, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (26) :15306-15311

[14] Nitric oxide binding properties of neuroglobin - A characterization by EPR and flash photolysis [J].

Van Doorslaer, S ;

Dewilde, S ;

Kiger, L ;

Nistor, SV ;

Goovaerts, E ;

Marden, MC ;

Moens, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (07) :4919-4925

[15] Oxidized human neuroglobin acts as a heterotrimeric Gα protein guanine nucleotide dissociation inhibitor [J].

Wakasugi, K ;

Nakano, T ;

Morishima, I .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (38) :36505-36512

[16] Myoglobin function reassessed [J].

Wittenberg, JB ;

Wittenberg, BA .

JOURNAL OF EXPERIMENTAL BIOLOGY, 2003, 206 (12) :2011-2020

[17] Localization of neuroglobin protein in the mouse brain [J].

Wystub, S ;

Laufs, T ;

Schmidt, M ;

Burmester, T ;

Maas, U ;

Saaler-Reinhardt, S ;

Hankeln, T ;

Reuss, S .

NEUROSCIENCE LETTERS, 2003, 346 (1-2) :114-116

[18]

WYSTUB S, IN PRESS CYTOGENET G

[19] Hemin induces neuroglobin expression in neural cells [J].

Zhu, YH ;

Sun, YJ ;

Jin, KL ;

Greenberg, DA .

BLOOD, 2002, 100 (07) :2494-2498