Resveratrol modulation of signal transduction in apoptosis and cell survival: A mini-review

被引:118
作者
Fulda, Simone [1 ]
Debatin, Klaus-Michael [1 ]
机构
[1] Univ Ulm, Childrens Hosp, D-89075 Ulm, Germany
来源
CANCER DETECTION AND PREVENTION | 2006年 / 30卷 / 03期
关键词
resveratrol; signaling network; MAPK signaling; signal transduction; mitochondrial pathway; NF-kappaB; tyrosine kinase pathway; survivin; chemoprevention; prevention; apoptosis; survival; cancer;
D O I
10.1016/j.cdp.2006.03.007
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: There is mounting evidence in the literature that resveratrol is a promising natural compound for prevention and treatment of a variety of human cancers. This overview summarizes recent studies of the major apoptosis and survival pathways regulated by resveratrol. Biological mechanisms: Apoptosis or programmed cell death is a key regulator of tissue homeostasis during normal development and also in adult organism under various conditions including adaptive responses to cellular stress For example, tissue homeostasis is maintained by tight control of signaling events regulating cell death and survival. Thus, uncontrolled proliferation or failure to undergo cell death is involved in pathogenesis and progression of many human diseases, for example in tumorigenesis or in cardiovascular disorders. Moreover, current cancer therapies primarily act by triggering apoptosis programs in cancer cells. Therapeutic applications: Natural products such as resveratrol have gained considerable attention as cancer chemopreventive or cardioprotective agents and also because of their antitumor properties. Among its wide range of biological activities, resveratrol has been reported to interfere with many intracellular signaling pathways, which regulate cell survival or apoptosis. Discussion: Further insights into the signaling network and interaction points modulated by resveratrol may provide the basis for novel drug discovery programs to exploit resveratrol for the prevention and treatment of human diseases. (c) 2006 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:217 / 223
页数:7
相关论文
共 63 条
[1]   Suppression of ultraviolet B exposure-mediated activation of NF-κB in normal human keratinocytes by resveratrol [J].
Adhami, VM ;
Afaq, F ;
Ahmad, N .
NEOPLASIA, 2003, 5 (01) :74-82
[2]   Validating survivin as a cancer therapeutic target [J].
Altieri, DC .
NATURE REVIEWS CANCER, 2003, 3 (01) :46-54
[3]   Survivin, versatile modulation of cell division and apoptosis in cancer [J].
Altieri, DC .
ONCOGENE, 2003, 22 (53) :8581-8589
[4]   Apoptosis control by death and decoy receptors [J].
Ashkenazi, A ;
Dixit, VM .
CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) :255-260
[5]   Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin [J].
Aziz, MH ;
Afaq, F ;
Ahmad, N .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2005, 81 (01) :25-31
[6]   Disruption of NF-κB signaling reveals a novel role for NF-κB in the regulation of TNF-related apoptosis-inducing ligand expression [J].
Baetu, TM ;
Kwon, H ;
Sharma, S ;
Grandvaux, N ;
Hiscott, J .
JOURNAL OF IMMUNOLOGY, 2001, 167 (06) :3164-3173
[7]  
Banerjee S, 2002, CANCER RES, V62, P4945
[8]   Rel/NF-κB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1 [J].
Bernard, D ;
Quatannens, B ;
Vandenbunder, B ;
Abbadie, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (29) :27322-27328
[9]   The Sir2 family of protein deacetylases [J].
Blander, G ;
Guarente, L .
ANNUAL REVIEW OF BIOCHEMISTRY, 2004, 73 :417-435
[10]   Oncogenic kinase signalling [J].
Blume-Jensen, P ;
Hunter, T .
NATURE, 2001, 411 (6835) :355-365