SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-infrared Imaging and Photothermal Heating

被引：371

作者：

von Maltzahn, Geoffrey ^{[1
]}

Centrone, Andrea ^{[4
]}

Park, Ji-Ho ^{[5
]}

Ramanathan, Renuka ^{[1
]}

Sailor, Michael J. ^{[5
,6
,7
]}

Hatton, T. Alan ^{[4
]}

Bhatia, Sangeeta N. ^{[1
,2
,3
]}

机构：

[1] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[2] Howard Hughes Med Inst, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, MIT, David H Koch Inst Integrat Canc Res, Boston, MA 02115 USA

[4] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[5] Univ Calif San Diego, Dept Chem & Biochem, Mat Sci & Engn Program, La Jolla, CA 92093 USA

[6] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[7] Univ Calif San Diego, Dept Nanoengn, La Jolla, CA 92093 USA

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 31期

基金：

美国国家卫生研究院;

关键词：

ENHANCED RAMAN-SCATTERING; SINGLE-MOLECULE; LIVE CELLS; NANOPARTICLES; SILVER; NANOSTRUCTURES; ABSORPTION; DEPENDENCE; THERAPY; SHAPE;

D O I：

10.1002/adma.200803464

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Screening nanorods coated with a mixture of SERS active molecules and biocompatible polymer identifies three formulations that may be uniquely distinguished in vivo over a spectral bandwidth of only 6 nm in the near-infrared (a spectral multiplexing density over an order of magnitude greater than attainable with semiconductor quantum dots, organic fluorochromes, and Raleigh scattering nanoparticle imaging approaches), while providing intense photothermal heating for cancer therapy. [GRAPHICS] .

引用

页码：3175 / +

页数：7

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