MiRNAs and Cancer

被引：366

作者：

Visone, Rosa

Croce, Carlo M. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2009年 / 174卷 / 04期

关键词：

CELL-CYCLE ARREST; MICRORNA EXPRESSION; POSTTRANSCRIPTIONAL REGULATION; DOWN-REGULATION; IN-VIVO; TARGET; GENES; RNA; SIGNATURES; PROGNOSIS;

D O I：

10.2353/ajpath.2009.080794

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Cancer is the result of a complex multistep process that involves the accumulation of sequential alterations of several genes, including those encoding microRNAs (miRNAs). miRNAs are a class of 17- to 27-nucleotide single-stranded RNA molecules that regulate gene expression posttranscriptionally. A large body of evidence implicates aberrant miRNA expression patterns in most, if not all, human malignancies. This article reviews our current knowledge about miRNAs, focusing on their involvement in cancer and their potential as diagnostic, prognostic, and therapeutic tools. (Ant J Pathol 2009, 174:1131-1138; DOI: 10.2353/ajpath.2009.080794)

引用

页码：1131 / 1138

页数：8

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