Inflammation: a mechanism of depression?

被引：80

作者：

Han, Qiu-Qin ^{[1
]}

Yu, Jin ^{[1
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Dept Integrat Med & Neurobiol, State Key Lab Med Neurobiol,Inst Brain Sci, Shanghai 200032, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2014年 / 30卷 / 03期

基金：

中国国家自然科学基金;

关键词：

depression; inflammation; cytokines; hypothalamic-pituitary-adrenal axis; 5-HT; neuroplasticity; NECROSIS-FACTOR-ALPHA; CENTRAL-NERVOUS-SYSTEM; PITUITARY-ADRENAL AXIS; CYTOKINE-INDUCED DEPRESSION; INTERFERON-ALPHA; GENE-EXPRESSION; MAJOR DEPRESSION; RAT-BRAIN; TNF-ALPHA; HPA-AXIS;

D O I：

10.1007/s12264-013-1439-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In recent decades, major depression has become more prevalent and research has shown that immune activation and cytokine production may be involved. This review is mainly focused on the contribution of inflammation to depression. We first briefly introduce the inflammatory biomarkers of depression, then discuss the sources of cytokines in the brain, and finally describe the neuroimmunological mechanisms underlying the association between inflammation and depression.

引用

页码：515 / 523

页数：9

共 104 条

[41] Cortisol, the cortisol-dehydroepiandrosterone ratio, and pro-inflammatory cytokines in patients with current major depressive disorder comorbid with borderline personality disorder
Kahl, KG
Bens, S
Ziegler, K
Rudolf, S
Dibbelt, L
Kordon, A
Schweiger, U
[J]. BIOLOGICAL PSYCHIATRY, 2006, 59 (07) : 667 - 671
[42] Suppression of cell proliferation by interferon-alpha through interleukin-1 production in adult rat dentate gyrus
Kaneko, Naoko
Kudo, Koutaro
Mabuchi, Tadashi
Takemoto, Keiko
Fujimaki, Koichiro
Wati, Henny
Iguchi, Hironobu
Tezuka, Hideo
Kanba, Shigenobu
[J]. NEUROPSYCHOPHARMACOLOGY, 2006, 31 (12) : 2619 - 2626
[43] Ketamine as a new treatment for depression: A review of its efficacy and adverse effects
Katalinic, Natalie
Lai, Rosalyn
Somogyi, Andrew
Mitchell, Philip B.
Glue, Paul
Loo, Colleen K.
[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2013, 47 (08) : 710 - 727
[44] SEX AND DEPRESSION IN THE NATIONAL COMORBIDITY SURVEY .1. LIFETIME PREVALENCE, CHRONICITY AND RECURRENCE
KESSLER, RC
MCGONAGLE, KA
SWARTZ, M
BLAZER, DG
NELSON, CB
[J]. JOURNAL OF AFFECTIVE DISORDERS, 1993, 29 (2-3) : 85 - 96
[45] Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood-brain barrier
Kitagami, T
Yamada, K
Miura, H
Hashimoto, R
Nabeshima, T
Ohta, T
[J]. BRAIN RESEARCH, 2003, 978 (1-2) : 104 - 114
[46] DEMONSTRATION OF INTERLEUKIN-3 RECEPTOR-ASSOCIATED ANTIGEN IN THE CENTRAL-NERVOUS-SYSTEM
KONISHI, Y
CHUI, DH
KUNISHITA, T
YAMAMURA, T
HIGASHI, Y
TABIRA, T
[J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1995, 41 (05) : 572 - 582
[47] Depression: an inflammatory illness?
Krishnadas, Rajeev
Cavanagh, Jonathan
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2012, 83 (05) : 495 - 502
[48] Cytokines and the brain: Implications for clinical psychiatry
Kronfol, Z
Remick, DG
[J]. AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (05) : 683 - 694
[49] Effect of interferon-alpha on DOI-induced wet-dog shakes in rats
Kugaya, A
Kagaya, A
Uchitomi, Y
Yokota, N
Yamawaki, S
[J]. JOURNAL OF NEURAL TRANSMISSION, 1996, 103 (8-9) : 947 - 955
[50] Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse
Kumagai, Naoko
Chiba, Yoichi
Hosono, Masamichi
Fujii, Masato
Kawamura, Noriko
Keino, Hiromi
Yoshikawa, Keisuke
Ishii, Sanae
Saitoh, Yuko
Satoh, Mamoru
Shimada, Atsuyoshi
Hosokawa, Masanori
[J]. BRAIN RESEARCH, 2007, 1185 : 75 - 85

← 1 2 3 4 5 6 7 8 9 10 →