The dark side of light: the damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis

被引：25

作者：

Hildesheim, J ^{[1
]}

Fornace, AJ ^{[1
]}

机构：

[1] NCI, Canc Res Ctr, Gene Response Sect, NIH, Bethesda, MD 20892 USA

来源：

DNA REPAIR | 2004年 / 3卷 / 06期

关键词：

keratinocyte; UV radiation; MAPK; oncogene; tumor suppressor;

D O I：

10.1016/j.dnarep.2004.02.012

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

引用

页码：567 / 580

页数：14

共 191 条

[91]

Liefer KM, 2000, CANCER RES, V60, P4016

[92] Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling [J].

Lin, AW ;

Barradas, M ;

Stone, JC ;

van Aelst, L ;

Serrano, M ;

Lowe, SW .

GENES & DEVELOPMENT, 1998, 12 (19) :3008-3019

[93] Persistent p53 mutations in single cells from normal human skin [J].

Ling, G ;

Persson, A ;

Berne, B ;

Uhlén, M ;

Lundeberg, J ;

Ponten, F .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (04) :1247-1253

[94] Expression of the apoptosis inhibitor survivin in aggressive squamous cell carcinoma [J].

Lo Muzio, L ;

Staibano, S ;

Pannone, G ;

Mignogna, MD ;

Mariggiò, A ;

Salvatore, G ;

Chieffi, P ;

Tramontano, D ;

De Rosa, G ;

Altieri, DC .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2001, 70 (03) :249-254

[95] EVIDENCE FOR AN EPIDERMAL CYTOKINE NETWORK [J].

LUGER, TA ;

SCHWARZ, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 95 (06) :S100-S104

[96] NONMELANOMA SKIN-CANCER IN THE UNITED-STATES - INCIDENCE [J].

MILLER, DL ;

WEINSTOCK, MA .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1994, 30 (05) :774-778

[97] Involvement of p16CDKN2A in cell cycle delays after low dose UV irradiation [J].

Milligan, A ;

Gabrielli, BG ;

Clark, JM ;

Hayward, NK ;

Ellem, KAO .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1998, 422 (01) :43-53

[98] p63 is a p53 homologue required for limb and epidermal morphogenesis [J].

Mills, AA ;

Zheng, BH ;

Wang, XJ ;

Vogel, H ;

Roop, DR ;

Bradley, A .

NATURE, 1999, 398 (6729) :708-713

[99] Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding [J].

Mita, H ;

Tsutsui, J ;

Takekawa, M ;

Witten, EA ;

Saito, H .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (13) :4544-4555

[100]

MITCHELL DL, 1988, PHOTOCHEM PHOTOBIOL, V48, P51

← 5 6 7 8 9 10 11 12 13 14 →