Fragment-based drug discovery

被引:507
作者
Erlanson, DA [1 ]
McDowell, RS [1 ]
O'Brien, T [1 ]
机构
[1] Sunesis Pharmaceut Inc, San Francisco, CA 94080 USA
关键词
D O I
10.1021/jm040031v
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:3463 / 3482
页数:20
相关论文
共 113 条
[1]   The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates [J].
Asante-Appiah, E ;
Patel, S ;
Dufresne, C ;
Roy, P ;
Wang, QP ;
Patel, V ;
Friesen, RW ;
Ramachandran, C ;
Becker, JW ;
Leblanc, Y ;
Kennedy, BP ;
Scapin, G .
BIOCHEMISTRY, 2002, 41 (29) :9043-9051
[2]   The properties of known drugs .1. Molecular frameworks [J].
Bemis, GW ;
Murcko, MA .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) :2887-2893
[3]   Properties of known drugs. 2. Side chains [J].
Bemis, GW ;
Murcko, MA .
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (25) :5095-5099
[4]   Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening [J].
Boehm, HJ ;
Boehringer, M ;
Bur, D ;
Gmuender, H ;
Huber, W ;
Klaus, W ;
Kostrewa, D ;
Kuehne, H ;
Luebbers, T ;
Meunier-Keller, N .
JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (14) :2664-2674
[5]  
Bohacek RS, 1996, MED RES REV, V16, P3, DOI 10.1002/(SICI)1098-1128(199601)16:1<3::AID-MED1>3.3.CO
[6]  
2-D
[7]  
Bohm H J, 1993, J Mol Recognit, V6, P131, DOI 10.1002/jmr.300060305
[8]   Discovery of a potent small molecule IL-2 inhibitor through fragment assembly [J].
Braisted, AC ;
Oslob, JD ;
Delano, WL ;
Hyde, J ;
McDowell, RS ;
Waal, N ;
Yu, C ;
Arkin, MR ;
Raimundo, BC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (13) :3714-3715
[9]   Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): Design, synthesis, enzymatic activities, and X-ray crystallographic analysis [J].
Bramson, HN ;
Corona, J ;
Davis, ST ;
Dickerson, SH ;
Edelstein, M ;
Frye, SV ;
Gampe, RT ;
Harris, PA ;
Hassell, A ;
Holmes, WD ;
Hunter, RN ;
Lackey, KE ;
Lovejoy, B ;
Luzzio, MJ ;
Montana, V ;
Rocque, WJ ;
Rusnak, D ;
Shewchuk, L ;
Veal, JM ;
Walker, DH ;
Kuyper, LF .
JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (25) :4339-4358