Novel C-ring analogues of 20(S)-camptothecin.: Part 3:: Synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues

被引：27

作者：

Subrahmanyam, D ^{[1
]}

Sarma, VM

Venkateswarlu, A

Sastry, TVRS

Srinivas, ASSV

Krishna, CV

Deevi, DS

Kumar, SA

Babu, MJ

Damodaran, NK

机构：

[1] Dr Reddys Res Fdn, Nat Prod Div, Hyderabad 500050, Andhra Pradesh, India

[2] Dr Reddys Res Fdn, Div Biotechnol, Hyderabad 500050, Andhra Pradesh, India

[3] Dr Reddys Res Fdn, Analyt Div, Hyderabad 500050, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)00005-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 5-substituted alkoxy 20(S)-camptothecin analogues having A- and B-ring substituents were prepared via semisynthesis. Most of these compounds were found to exhibit potent anti-cancer activity based on their in vitro cytotoxicity data obtained against human tumor cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：369 / 371

页数：3

共 9 条

[1] SOME PRACTICAL CONSIDERATIONS AND APPLICATIONS OF THE NATIONAL-CANCER-INSTITUTE IN-VITRO ANTICANCER DRUG DISCOVERY SCREEN [J].

BOYD, MR ;

PAULI, KD .

DRUG DEVELOPMENT RESEARCH, 1995, 34 (02) :91-109

[2] DISPLAY AND ANALYSIS OF PATTERNS OF DIFFERENTIAL ACTIVITY OF DRUGS AGAINST HUMAN-TUMOR CELL-LINES - DEVELOPMENT OF MEAN GRAPH AND COMPARE ALGORITHM [J].

PAULL, KD ;

SHOEMAKER, RH ;

HODES, L ;

MONKS, A ;

SCUDIERO, DA ;

RUBINSTEIN, L ;

PLOWMAN, J ;

BOYD, MR .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (14) :1088-1092

[3]

SAWADA S, 1991, CHEM PHARM BULL, V39, P2574

[4]

SAWADA S, 1991, CHEM PHARM BULL, V39, P3183

[5] Novel C-ring analogues of 20(S)-camptothecin-Part-2:: Synthesis and in vitro cytotoxicity of 5-C-substituted 20(S)-camptothecin analogues [J].

Subrahmanyam, D ;

Venkateswarlu, A ;

Rao, KV ;

Sastry, TVRS ;

Vandana, G ;

Kumar, SA .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (12) :1633-1638

[6] In vitro cytotoxicity of 5-aminosubstituted 20(S)-camptothecins.: Part 1 [J].

Subrahmanyam, D ;

Sarma, VM ;

Venkateswarlu, A ;

Sastry, TVRS ;

Kulakarni, AP ;

Rao, DS ;

Reddy, KVSRK .

BIOORGANIC & MEDICINAL CHEMISTRY, 1999, 7 (09) :2013-2020

[7] PLANT ANTITUMOR AGENTS .30. SYNTHESIS AND STRUCTURE-ACTIVITY OF NOVEL CAMPTOTHECIN ANALOGS [J].

WALL, ME ;

WANI, MC ;

NICHOLAS, AW ;

MANIKUMAR, G ;

TELE, C ;

MOORE, L ;

TRUESDALE, A ;

LEITNER, P ;

BESTERMAN, JM .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (18) :2689-2700

[8] THE SYNTHESIS OF 5-SUBSTITUTED CAMPTOTHECINS AS POTENTIAL INHIBITORS OF DNA TOPOISOMERASE-I [J].

WANG, HK ;

LIU, SY ;

HWANG, KM ;

MCPHAIL, AT ;

LEE, KH .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (01) :77-82

[9] AN EFFICIENT CONVERSION OF CAMPTOTHECIN TO 10-HYDROXYCAMPTOTHECIN [J].

WOOD, JL ;

FORTUNAK, JM ;

MASTROCOLA, AR ;

MELLINGER, M ;

BURK, PL .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (17) :5739-5740

← 1 →