The role of CD4+ T cell help in cancer immunity and the formulation of novel cancer vaccines

被引：31

作者：

Assudani, Deepak P. ^{[1
]}

Horton, Roger B. V. ^{[1
]}

Mathieu, Morgan G. ^{[1
]}

McArdle, Stephanie E. B. ^{[1
]}

Rees, Robert C. ^{[1
]}

机构：

[1] Nottingham Trent Univ, Sch Biomed & Nat Sci, Nottingham NG11 8NS, England

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2007年 / 56卷 / 01期

关键词：

D O I：

10.1007/s00262-006-0154-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent years have seen the unprecedented surge of interest in the role of CD4+ T cells and the role they play in the development of the immune response. In this symposium review, we examine the evidence for this and discuss their functions, particularly in respect to the cancer immunology, including CD4+CD25+ cells (Treg).

引用

页码：70 / 80

页数：11

共 104 条

[71] CD8+ T cells mediate CD40-independent maturation of dendritic cells in vivo [J].

Ruedl, C ;

Kopf, M ;

Bachmann, MF .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (12) :1875-1883

[72] Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma [J].

Salgia, R ;

Lynch, T ;

Skarin, A ;

Lucca, J ;

Lynch, C ;

Jung, K ;

Hodi, FS ;

Jaklitsck, M ;

Mentzer, S ;

Swanson, S ;

Lukanich, J ;

Buena, R ;

Wain, J ;

Mathisen, D ;

Wright, C ;

Fidias, P ;

Donahue, D ;

Clift, S ;

Hardy, S ;

Neuberg, D ;

Mulligan, R ;

Webb, I ;

Sugarbaker, D ;

Mihm, M ;

Dranoff, G .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (04) :624-630

[73] CD4(+) T-cell induction of fas-mediated apoptosis in Burkitt's lymphoma B cells [J].

Schattner, EJ ;

Mascarenhas, J ;

Bishop, J ;

Yoo, DH ;

Chadburn, A ;

Crow, MK ;

Freidman, SM .

BLOOD, 1996, 88 (04) :1375-1382

[74] Clinical trials of antitumor vaccination with an autologous tumor cell vaccine modified by virus infection: improvement of patient survival based on improved antitumor immune memory [J].

Schirrmacher, V .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2005, 54 (06) :587-598

[75] T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions [J].

Schoenberger, SP ;

Toes, REM ;

van der Voort, EIH ;

Offringa, R ;

Melief, CJM .

NATURE, 1998, 393 (6684) :480-483

[76]

SCHWARTZ RH, 1989, COLD SH Q B, V54, P605

[77] Cutting edge:: IL-10-producing CD4+ T cells mediate tumor rejection [J].

Segal, BM ;

Glass, DD ;

Shevach, EM .

JOURNAL OF IMMUNOLOGY, 2002, 168 (01) :1-4

[78] Requirement for CD4 T cell help in generating functional CD8 T cell memory [J].

Shedlock, DJ ;

Shen, H .

SCIENCE, 2003, 300 (5617) :337-339

[79] Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity [J].

Smith, CM ;

Wilson, NS ;

Waithman, J ;

Villadangos, JA ;

Carbone, FR ;

Heath, WR ;

Belz, GT .

NATURE IMMUNOLOGY, 2004, 5 (11) :1143-1148

[80] Vaccination with irradiated, autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma [J].

Soiffer, R ;

Hodi, FS ;

Haluska, F ;

Jung, K ;

Gillessen, S ;

Singer, S ;

Tanabe, K ;

Duda, R ;

Mentzer, S ;

Jaklitsch, M ;

Bueno, R ;