G protein-dependent activation of mast cell by peptides and basic secretagogues

被引：131

作者：

Ferry, X ^{[1
]}

Brehin, S ^{[1
]}

Kamel, R ^{[1
]}

Landry, Y ^{[1
]}

机构：

[1] Univ Louis Pasteur Strasbourg 1, Fac Pharm, Lab Neuroimmunopharmacol, INSERM,U425, F-67401 Illkirch Graffenstaden, France

来源：

PEPTIDES | 2002年 / 23卷 / 08期

关键词：

basic secretagogues; mast cells; G proteins; cell-penetrating peptides; neuropeptides; venom peptides; defensins; compound; 48/80; mastoparan;

D O I：

10.1016/S0196-9781(02)00090-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signaling pathways leading to exocytosis and arachidonate release from serosal mast cells by basic secretagogues, including cationic peptides, arise from the involvement of betagamma subunits from G(i2) and G(i3) GTP-binding proteins. The original concept that basic secretagogues directly interact with G proteins implicated the entry of secretagogues into mast cells. This has been demonstrated only for the neuropeptide substance P. Basic secretagogues might share a common mechanism of penetration with the newly described cell-penetrating peptides. The involvement of some membrane transporter or non-selective membrane receptor to basic secretagogues cannot be excluded. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：1507 / 1515

页数：9

共 106 条

[61] Mechanism of peptide-induced mast cell degranulation - Translocation and patch-clamp studies [J].