Pax-2 in the chiasm

被引：21

作者：

AlvarezBolado, G ^{[1
]}

Schwarz, M ^{[1
]}

Gruss, P ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,ABT MOL ZELLBIOL,D-37077 GOTTINGEN,GERMANY

来源：

CELL AND TISSUE RESEARCH | 1997年 / 290卷 / 02期

关键词：

Pax-2; optic chiasm; axonal guidance; Sonic hedgehog; mutant mice; zebrafish;

D O I：

10.1007/s004410050923

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pax genes are expressed in specific patterns in the nervous system during development and in the adult. Recent findings suggest a link between the expression of Pax-2 and axonal guidance. Mice with a targeted deletion of Pax-2 are an excellent tool for studying axonal pathfinding at the molecular level, especially with respect to the optic chiasm. The date reviewed here suggest that Pax-2 regulates the expression of surface molecules involved in contact attraction and that the mutual regulation of the expression of Pax-2 and the Sonic hedgehog gene is of importance in the formation of the chiasm region.

引用

页码：197 / 200

页数：4