Molecular modeling of enantiomeric resolution of methylphenidate on cellulose tris benzoate chiral stationary phase

被引：16

作者：

Aboul-Enein, HY

Ali, M

Laguerre, M

Felix, G

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Biol & Med Res Dept MBC03, Pharmaceut Anal Lab, Riyadh 11211, Saudi Arabia

[2] ENSCPB, Ecole Polytech, IECB, F-33607 Pessac, France

[3] ENSCPB, F-33402 Talence, France

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2002年 / 25卷 / 18期

关键词：

D O I：

10.1081/JLC-120014946

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomeric resolution of (+/-)-threo methylphenidate (MPH) (Ritalin(R)) has been achieved on Chiralcel OB column using the mobile phase hexane-ethanol-methanol-trifluoroacetic acid (480:9.75:9.75 :0.5, v/v/v/v), containing benzoic acid and phenol as mobile phase additives. Ultraviolet detection was carried out at 230 nm. Molecular modeling was carried out to explain the chiral resolution mechanism of MPH enantiomers.

引用

页码：2739 / 2748

页数：10

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