Patterns of consent in epidemiologic research: Evidence from over 25,000 responders

被引:147
作者
Dunn, KM [1 ]
Jordan, K [1 ]
Lacey, RJ [1 ]
Shapley, M [1 ]
Jinks, C [1 ]
机构
[1] Univ Keele, Primary Care Sci Res Ctr, Keele ST5 5BG, Staffs, England
基金
英国医学研究理事会;
关键词
bias (epidemiology); consent forms; epidemiologic methods; informed consent; longitudinal studies; medical records; selection bias;
D O I
10.1093/aje/kwh141
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Ethical guidelines in the United Kingdom require written consent from participants in epidemiologic studies for follow-up or review of medical records. This may cause bias in samples used for follow-up or medical record review. The authors analyzed data from seven general population surveys conducted in the United Kingdom (1996-2002), to which over 25,000 people responded. Associations of age, gender, and symptom under investigation with consent to follow-up and consent to review of medical records were examined. Consent to follow-up was approximately 75-95% among survey responders under age 50 years but fell among older people, particularly females. Consent to follow-up was also higher among responders who had the symptom under investigation (pooled odds ratio = 1.61, 95% confidence interval: 1.36, 1.92). Consent to review of medical records followed a similar pattern. Patterns of consent were relatively consistent and represented a high proportion of responders. Males, younger people, and subjects reporting the symptom under investigation were more likely to give consent, and these groups may be overrepresented in follow-up samples or reviews of medical records. Although consent is high among responders, the additive effect of nonresponse and nonconsent can substantially reduce sample size and should be taken into account in epidemiologic study planning.
引用
收藏
页码:1087 / 1094
页数:8
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