Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans

被引:97
作者
Matzinger, D
Gutzwiller, JP
Drewe, J
Orban, A
Engel, R
D'Amato, M
Rovati, L
Beglinger, C [1 ]
机构
[1] Univ Basel Hosp, Div Gastroenterol, CH-4031 Basel, Switzerland
[2] Univ Basel Hosp, Dept Res, CH-4031 Basel, Switzerland
[3] Rotta Res Lab SpA, I-20052 Monza, Italy
关键词
intraduodenal fat; gastric distension; appetite;
D O I
10.1152/ajpregu.1999.277.6.R1718
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Intraduodenal fat inhibits gastric emptying and exerts early satiation in animals and humans, but it is not dear whether the effects are mediated by cholecystokinin (CCK) in humans. Here, we tested whether CCK-A receptors mediate the inhibition of fat on food intake. Two sequential, double-blind, crossover studies were performed in 24 male subjects. First, subjects received either intraduodenal fat or saline together with a preload of either water or banana shake. Second, 12 subjects received either intraduodenal fat or saline perfusion plus a concomitant infusion of saline or loxiglumide, a specific CCK-A receptor antagonist, together with a preload of banana shake. In both studies, subjects were free to eat and drink as much as they wished. Fat induced a reduction in calorie intake (P < 0.05) compared with controls. Furthermore, a decrease in hunger feelings was observed. Infusion of loxiglumide abolished the effects of fat. Duodenal fat interacts with an appetizer to modulate energy intake in humans. This effect is mediated by CCK-A receptors.
引用
收藏
页码:R1718 / R1724
页数:7
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