Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans

被引:97
作者
Matzinger, D
Gutzwiller, JP
Drewe, J
Orban, A
Engel, R
D'Amato, M
Rovati, L
Beglinger, C [1 ]
机构
[1] Univ Basel Hosp, Div Gastroenterol, CH-4031 Basel, Switzerland
[2] Univ Basel Hosp, Dept Res, CH-4031 Basel, Switzerland
[3] Rotta Res Lab SpA, I-20052 Monza, Italy
关键词
intraduodenal fat; gastric distension; appetite;
D O I
10.1152/ajpregu.1999.277.6.R1718
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Intraduodenal fat inhibits gastric emptying and exerts early satiation in animals and humans, but it is not dear whether the effects are mediated by cholecystokinin (CCK) in humans. Here, we tested whether CCK-A receptors mediate the inhibition of fat on food intake. Two sequential, double-blind, crossover studies were performed in 24 male subjects. First, subjects received either intraduodenal fat or saline together with a preload of either water or banana shake. Second, 12 subjects received either intraduodenal fat or saline perfusion plus a concomitant infusion of saline or loxiglumide, a specific CCK-A receptor antagonist, together with a preload of banana shake. In both studies, subjects were free to eat and drink as much as they wished. Fat induced a reduction in calorie intake (P < 0.05) compared with controls. Furthermore, a decrease in hunger feelings was observed. Infusion of loxiglumide abolished the effects of fat. Duodenal fat interacts with an appetizer to modulate energy intake in humans. This effect is mediated by CCK-A receptors.
引用
收藏
页码:R1718 / R1724
页数:7
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  • [21] C-TERMINAL OCTAPEPTIDE OF CHOLECYSTOKININ DECREASES FOOD-INTAKE IN MAN
    KISSILEFF, HR
    PISUNYER, FX
    THORNTON, J
    SMITH, GP
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1981, 34 (02) : 154 - 160
  • [22] REGULATION OF GASTRIC-EMPTYING IN HUMANS BY CHOLECYSTOKININ
    LIDDLE, RA
    MORITA, ET
    CONRAD, CK
    WILLIAMS, JA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (03) : 992 - 996
  • [23] CHOLECYSTOKININ BIOACTIVITY IN HUMAN-PLASMA - MOLECULAR-FORMS, RESPONSES TO FEEDING, AND RELATIONSHIP TO GALLBLADDER CONTRACTION
    LIDDLE, RA
    GOLDFINE, ID
    ROSEN, MS
    TAPLITZ, RA
    WILLIAMS, JA
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (04) : 1144 - 1152
  • [24] LIDDLE RA, 1984, GASTROENTEROLOGY, V87, P542
  • [25] EFFECTS OF A PHYSIOLOGICAL DOSE OF CHOLECYSTOKININ ON FOOD-INTAKE AND POSTPRANDIAL SATIATION IN MAN
    LIEVERSE, RJ
    JANSEN, JBMJ
    VANDEZWAN, A
    SAMSON, L
    MASCLEE, AAM
    LAMERS, CBHW
    [J]. REGULATORY PEPTIDES, 1993, 43 (1-2) : 83 - 89
  • [26] SATIETY EFFECTS OF CHOLECYSTOKININ IN HUMANS
    LIEVERSE, RJ
    JANSEN, JBMJ
    MASCLEE, AAM
    LAMERS, CBHW
    [J]. GASTROENTEROLOGY, 1994, 106 (06) : 1451 - 1454
  • [27] SATIETY EFFECTS OF THE TYPE-A CCK RECEPTOR ANTAGONIST LOXIGLUMIDE IN LEAN AND OBESE WOMEN
    LIEVERSE, RJ
    MASCLEE, AAM
    JANSEN, JBMJ
    ROVATI, LC
    LAMERS, CBHW
    [J]. BIOLOGICAL PSYCHIATRY, 1995, 37 (05) : 331 - 335
  • [28] EFFECT OF A LOW-DOSE OF INTRADUODENAL FAT ON SATIETY IN HUMANS - STUDIES USING THE TYPE-A CHOLECYSTOKININ RECEPTOR ANTAGONIST LOXIGLUMIDE
    LIEVERSE, RJ
    JANSEN, JBMJ
    MASCLEE, AAM
    ROVATI, LC
    LAMERS, CBHW
    [J]. GUT, 1994, 35 (04) : 501 - 505
  • [29] LILJA P, 1984, SURG GYNECOL OBSTET, V159, P557
  • [30] MCHUGH PR, 1986, FASEB J, V45, P1384