Regulation of lymphocyte adhesion and migration by the small GTPase Rap1 and its effector molecule, RAPL

被引：78

作者：

Kinashi, T ^{[1
]}

Katagiri, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Bayer Chair Dept Mol Immunol & Allergy, Sakyo Ku, Kyoto 6068501, Japan

来源：

IMMUNOLOGY LETTERS | 2004年 / 93卷 / 01期

关键词：

Rap; 1; RAPL; LFA-1;

D O I：

10.1016/j.imlet.2004.02.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dynamic regulation of integrin-mediated adhesion is central to lymphocyte trafficking and antigen recognition. The small GTPase Rapt is a potent stimulator of leukocyte integrins through modulation of affinity and avidity. In addition, lymphocyte Rap1 has unique abilities to trigger cell polarization and enhance cell motility. These characteristics of Rap1 contribute to adhesive interactions with antigen-presenting cells (APC) and the vascular endothelium. In the process of elucidating the molecular mechanisms of Rap1-mediated integrin activation, we have identified a novel Rap1-binding molecule, regulator of adhesion and cell polarization enriched in lymphoid tissues (RAPL). RAPL is predominantly expressed in immune cells, and mediates Rap1-triggered integrin activation upon TCR engagement and chemokine stimulation. Importantly, Rap1/RAPL signaling cooperatively regulates cell polarization and integrin activation. The linkage between cell polarization and integrin activation through Rap1/RAPL signaling likely provides immune cells with their dynamic trafficking capability. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1 / 5

页数：5

共 31 条

[1] LAD-III, a novel group of leukocyte integrin activation deficiencies [J].

Alon, R ;

Etzioni, A .

TRENDS IN IMMUNOLOGY, 2003, 24 (10) :561-566

[2]

Amsen D, 2000, EUR J IMMUNOL, V30, P2832, DOI 10.1002/1521-4141(200010)30:10<2832::AID-IMMU2832>3.0.CO

[3]

2-D

[4] Relationships between Rap1b, affinity modulation of integrin αIIbβ3, and the actin cytoskeleton [J].

Bertoni, A ;

Tadokoro, S ;

Eto, K ;

Pampori, N ;

Parise, LV ;

White, GC ;

Shattil, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (28) :25715-25721

[5] Rap1 signalling: Adhering to new models [J].

Bos, JL ;

de Rooij, J ;

Reedquist, KA .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (05) :369-377

[6] Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1 [J].

Boussiotis, VA ;

Freeman, GJ ;

Berezovskaya, A ;

Barber, DL ;

Nadler, LM .

SCIENCE, 1997, 278 (5335) :124-128

[7] Integrin avidity regulation: are changes in affinity and conformation underemphasized? [J].

Carman, CV ;

Springer, TA .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (05) :547-556

[8] The GTPase Rap1 controls functional activation of macrophage integrin αMβ2 by LPS and other inflammatory mediators [J].

Caron, E ;

Self, AJ ;

Hall, A .

CURRENT BIOLOGY, 2000, 10 (16) :974-978

[9] T-CELL RECEPTOR CROSS-LINKING TRANSIENTLY STIMULATES ADHESIVENESS THROUGH LFA-1 [J].

DUSTIN, ML ;

SPRINGER, TA .

NATURE, 1989, 341 (6243) :619-624

[10] T-cell integrins: more than just sticking points [J].

Hogg, N ;

Laschinger, M ;

Giles, K ;

McDowall, A .

JOURNAL OF CELL SCIENCE, 2003, 116 (23) :4695-4705

← 1 2 3 4 →