Inhibition of MMP-2 activation and release as a novel mechanism for HDL-induced cardioprotection

被引：16

作者：

Bellosta, Stefano ^{[1
]}

Gomaraschi, Monica ^{[1
]}

Canavesi, Monica ^{[1
]}

Rossoni, Giuseppe ^{[1
]}

Monetti, Mara ^{[1
]}

Franceschini, Guido ^{[1
]}

Calabresi, Laura ^{[1
]}

机构：

[1] Univ Milan, Dept Pharmacol Sci, Ctr E Grossi Paoletti, I-20133 Milan, Italy

来源：

FEBS LETTERS | 2006年 / 580卷 / 25期

关键词：

high density lipoproteins; gelatinase A; matrix metalloproteinases; myocardial ischemia; ischemia/reperfusion injury;

D O I：

10.1016/j.febslet.2006.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High density lipoproteins (HDL) protect the heart against ischemia/reperfusion (I/R) injury, and matrix metalloproteinase-2 (MMP-2) directly contributes to cardiac contractile dysfunction after I/R. To investigate the possible involvement of MMP-2 inhibition in HDL-mediated cardioprotection, isolated rat hearts underwent 20 min of low-flow ischemia and 30 min of reperfusion. Plasma-derived and synthetic HDL attenuated the I/R-induced cardiac MMP-2 activation and release in a dose-dependent way. The attenuation of I/R-induced MMP-2 activation by HDL correlated with the reduction of post-ischemic contractile dysfunction and cardiomyocyte necrosis. These results indicate prevention of MMP-2 activation as a novel mechanism for HDL-mediated cardioprotection. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：5974 / 5978

页数：5

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