2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer

被引：769

作者：

Farge, Dominique ^{[1
,3
]}

Frere, Corinne ^{[4
]}

Connors, Jean M. ^{[5
]}

Ay, Cihan ^{[6
]}

Khorana, Alok A. ^{[7
,8
]}

Muno, Andres Z. ^{[9
]}

Brenner, Benjamin ^{[10
]}

Kakkar, Ajay ^{[11
,12
]}

Rafii, Hanadi ^{[2
]}

Solymoss, Susan ^{[3
]}

Brilhante, Dialina ^{[13
]}

Monreal, Manuel ^{[14
]}

Bounameaux, Henri ^{[15
]}

Pabinger, Ingrid ^{[6
]}

Douketis, James ^{[16
]}

机构：

[1] Univ Paris, Ctr Reference Rare Syst Autoimmune Dis FAI2R, Internal Med UF04, Autoimmune & Vasc Dis Unit, Paris, France

[2] Univ Paris, St Louis Hosp, AP HP, Eurocord, Paris, France

[3] McGill Univ, Dept Med, Montreal, PQ H4A 3J1, Canada

[4] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Haematol,UMRS 1166, Paris, France

[5] Harvard Med Sch, Brigham & Womens Hosp, Hematol Div, Boston, MA 02115 USA

[6] Med Univ Vienna, Dept Med 1, Clin Div Hematol & Hemostaseol, Vienna, Austria

[7] Cleveland Clin, Taussig Canc Inst, Cleveland, OH 44106 USA

[8] Cleveland Clin, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

[9] Univ Complutense, Hosp Gen Univ Gregorio Maranon, Med Oncol Dept, Madrid, Spain

[10] Rambam Hlth Care Campus, Dept Hematol & Bone Marrow Transplantat, Haifa, Israel

[11] Thrombosis Res Inst, London, England

[12] UCL, London, England

[13] Lisbon Ctr, Francisco Gentil Portuguese Inst Oncol, Lisbon, Portugal

[14] Univ Catolica Murcia, Hosp Germans Trias & Pujol, Dept Internal Med, Barcelona, Spain

[15] Univ Hosp Geneva, Fac Med, Div Angiol & Hemostasis, Geneva, Switzerland

[16] McMaster Univ, Dept Med, Hamilton, ON, Canada

来源：

LANCET ONCOLOGY | 2019年 / 20卷 / 10期

关键词：

MOLECULAR-WEIGHT HEPARIN; VENA-CAVA FILTERS; DIRECT ORAL ANTICOAGULANTS; AMBULATORY PATIENTS; RECEIVING CHEMOTHERAPY; LUNG-CANCER; PHARMACOLOGICAL THROMBOPROPHYLAXIS; DALTEPARIN THROMBOPROPHYLAXIS; THERAPEUTIC ANTICOAGULATION; INTRACRANIAL HEMORRHAGE;

D O I：

10.1016/S1470-2045(19)30336-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Venous thromboembolism (VTE) is the second leading cause of death in patients with cancer. These patients are at a high risk of VTE recurrence and bleeding during anticoagulant therapy. The International Initiative on Thrombosis and Cancer is an independent academic working group aimed at establishing a global consensus for the treatment and prophylaxis of VTE in patients with cancer. The International Initiative on Thrombosis and Cancer last updated its evidence-based clinical practice guidelines in 2016 with a free, web-based mobile phone application, which was subsequently endorsed by the International Society on Thrombosis and Haemostasis. The 2019 International Initiative on Thrombosis and Cancer clinical practice guidelines, which are based on a systematic review of the literature published up to December, 2018, are presented along with a Grading of Recommendations Assessment Development and Evaluation scale methods, with the support of the French National Cancer Institute. These guidelines were reviewed by an expanded international advisory committee and endorsed by the International Society on Thrombosis and Haemostasis. Results from head-to-head clinical trials that compared direct oral anticoagulant with low-molecular-weight heparin are also summarised, along with new evidence for the treatment and prophylaxis of VTE in patients with cancer.

引用

页码：E566 / E581

页数：16

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