High-dose 308-nm excimer laser for the treatment of psoriasis

Background: The excimer laser can deliver high-intensity. ultraviolet B (UVB) energy at 308 nm, a wavelength similar to that Used in narrow-band UVB phototherapy. Objective: The goal of this investigation was to evaluate the role of high-close single treatments with the excimer 308-nm laser in stable plaque-type psoriasis. Methods: Eighteen volunteers were enrolled in the study. Two plaques were selected and half of each plaque was held as a control while the other half was treated with a single dose of either 8 or 16 times the minimal erythema close. Results: Sixteen subjects completed the Study, Two patients signed up but never actually participated because of Scheduling problems. Eleven showed significant improvement within 1 month, and 5 still demonstrated persistent areas of clearing at 4 months. Conclusion: As little as one high-close excimer laser treatment can be effective for localized plaque-type psoriasis. Multiple treatments or other irradiation schedules With this innovative device may prove even more efficacious.