Bridgehead enolates and bridgehead alkenes in a welwistatin model series

被引:22
作者
Boissel, Valerie [2 ]
Simpkins, Nigel S. [2 ]
Bhalay, Gurdip [1 ]
Blake, Alexander J. [2 ]
Lewis, William [2 ]
机构
[1] Horsham Res Ctr, Novartis Inst Biomed Res, Global Discovery Chem, Horsham, W Sussex, England
[2] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
关键词
SKELETON; WELWITINDOLINONES; CLUSIANONE; EFFICIENT;
D O I
10.1039/b820674k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Bridgehead metallation is possible in a ketone having the welwistatin skeleton, and this facilitates installation of the isothiocyanate function present in the natural product, and also enables synthesis of remarkable bridgehead alkenes.
引用
收藏
页码:1398 / 1400
页数:3
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