Improvements in cross coupling reactions of hypervalent siloxane derivatives

被引：151

作者：

Mowery, ME ^{[1
]}

DeShong, P ^{[1
]}

机构：

[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 13期

关键词：

D O I：

10.1021/ol991186d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The scope of the palladium-catalyzed cross coupling reaction of aryl halides with phenyltrimethoxysilane has been expanded to include aryl bromides, heteroaryl bromides, and aryl chlorides; A more general Pd(0)-catalyst/ligand system has been developed to activate bromides: palladium(ll) acetate (Pd(OAc)(2)) is activated with triphenylphosphine (PPh3) or tri-o-tolylphosphine (P(o-tol)(3)) (1:2 molar ratio of Pd:phosphine). Coupling of aryl chloride derivatives required addition of 2-(dicyclohexylphosphino)biphenyl (Buchwald's ligand) to Pd(2)dba(3) (tris(dibenzylideneacetone)dipalladium(0)) (1:1.5 molar ratio of Pd:phosphine).

引用

页码：2137 / 2140

页数：4

共 33 条

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