Preparation of soluble and insoluble polymer supported IBX reagents

被引：74

作者：

Reed, NN ^{[1
]}

Delgado, M ^{[1
]}

Hereford, K ^{[1
]}

Clapham, B ^{[1
]}

Janda, KD ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(02)00264-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of soluble and insoluble polymer supported versions of the versatile oxidizing reagent IBX has been prepared. Each of the reagents were evaluated for their efficiency in the conversion of benzyl alcohol to benzaldehyde. Results from this study were that the soluble, non-crosslinked polystyrene supported IBX reagent gave the best rate of conversion to benzaldehyde, while the macroporous polymer supported IBX resin provided a superior rate of conversion to benzaldehyde when compared with a gel type resin. The macroporous IBX reagent was also shown to convert a series of alcohols to the corresponding aldehydes and ketones. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2047 / 2049

页数：3

共 21 条

[1] POLYMER-SUPPORTED ALKYL AZODICARBOXYLATES FOR MITSUNOBU REACTIONS [J].