A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

被引：646

作者：

Lacronique, V

Boureux, A

DellaValle, V

Poirel, H

Quang, CT

Mauchauffe, M

Berthou, C

Lessard, M

Berger, R

Ghysdael, J

Bernard, OA

机构：

[1] INST GENET MOL, INSERM, U301, F-75010 PARIS, FRANCE

[2] INST GENET MOL, CNRS, SD 401 301, F-75010 PARIS, FRANCE

[3] CTR UNIV ORSAY, INST CURIE, SECT RECH, CNRS, UNITE MIXTE RECH 146, F-91405 ORSAY, FRANCE

[4] CTR HOSP REG BREST, HOP MORVAN, LAB CYTOGENET, UNITE HEMATOL, F-29609 BREST, FRANCE

来源：

SCIENCE | 1997年 / 278卷 / 5341期

关键词：

D O I：

10.1126/science.278.5341.1309

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Janus family of tyrosine kinases (JAK) plays an essential role in development and in coupling cytokine receptors to downstream intracellular signaling events. A t(9;12)(p24;p13) chromosomal translocation in a T cell childhood acute lymphoblastic leukemia patient was characterized and shown to fuse the 3' portion of JAK2 to the 5' region of TEL, a gene encoding a member of the ETS transcription factor family, The TEL-JAK2 fusion protein includes the catalytic domain of JAK2 and the TEL-specific oligomerization domain, TEL-induced oligomerization of TEL-JAK2 resulted in the constitutive activation of its tyrosine kinase activity and conferred cytokine-independent proliferation to the interleukin-3-dependent Ba/F3 hematopoietic cell line.

引用

页码：1309 / 1312

页数：4

共 25 条

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