Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease

被引：78

作者：

Geula, C

Darvesh, S

机构：

[1] Beth Israel Deaconess Med Ctr, Lab Neurogenerat & Aging Res, Burlington Res Facil, Div Gerontol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Dept Med Neurosci, Lab Neurogenerat & Aging Res, Boston, MA 02215 USA

[3] Dalhousie Univ, Dept Med Neurol & Geriat Med, Halifax, NS, Canada

[4] Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS, Canada

来源：

DRUGS OF TODAY | 2004年 / 40卷 / 08期

关键词：

D O I：

10.1358/dot.2004.40.8.850473

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Butyrylcholinesterase is a serine hydrolase biochemically related to the cholinergic enzyme acetylcholinesterase. It is capable of. hydrolyzing esters of choline. Butyrylcholinesterase has unique enzymatic properties and is widely distributed in the nervous system, raising the possibility of its involvement in neural function. In particular, recent evidence indicates that along with acetylcholinesterase, butyrylcholinesterase catalyzes the hydrolysis of acetylcholine, and thus serves as a co-regulator of cholinergic transmission. Accumulating evidence also indicates that butyrylcholinesterase is likely to be involved in neurodegenerative disorders such as Alzheimer's disease. Therefore, inhibition of butyrylcholinesterase will not only lead to enhanced cholinergic transmission but also has the potential to interfere with the disease process in Alzheimer's disease and other dementing disorders. (C) 2004 Prous Science. All rights reserved.

引用

页码：711 / 721

页数：11

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