Synthesis of betulin derivatives and their protective effects against the cytotoxicity of cadmium

被引：39

作者：

Hiroya, K ^{[1
]}

Takahashi, T ^{[1
]}

Miura, N ^{[1
]}

Naganuma, A ^{[1
]}

Sakamoto, T ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 10期

关键词：

D O I：

10.1016/S0968-0896(02)00172-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protecting effect of betulin against cadmium toxicity was investigated using 11 kinds of analogues. It was elucidated by analyzing the analogue activities that both hydroxyl groups on C-3 and C-28 and the isopropenyl group on C-19 played important roles for expressing efficient activities. In addition, the cytotoxicity of betulin was also reduced by being functionalized using the above functional group. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3229 / 3236

页数：8

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