Catalysis of the Kemp elimination by antibodies elicited against a cationic hapten

被引：28

作者：

GenreGrandpierre, A

Tellier, C

Loirat, MJ

Blanchard, D

Hodgson, DRW

Hollfelder, F

Kirby, AJ

机构：

[1] FAC SCI & TECH,UPRES 2161 BIOCATALYSE,F-44322 NANTES 03,FRANCE

[2] CRTS,F-44011 NANTES 01,FRANCE

[3] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CB2 1EW,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(97)10003-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rather efficient catalysis of the decomposition of 5-nitro-benzisoxazole to the cyanophenol was observed with antibodies elicited against a cationic hapten structurally unrelated to the benzisoxazole substrate. The rate enhancement by the most active antibody is better than 10(4) and the reaction is catalyzed by a carboxylate group associated with a hydrophobic binding site. (C) 1997 Elsevier Science Ltd.

引用

页码：2497 / 2502

页数：6

共 24 条

[21] TRANSITION-STATE STABILIZATION AS A MEASURE OF THE EFFICIENCY OF ANTIBODY CATALYSIS [J].