Rho/ROCK signaling in motility and metastasis of gastric cancer

被引：143

作者：

Matsuoka, Tasuku ^{[1
]}

Yashiro, Masakazu ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Surg Oncol, Osaka 5458585, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 38期

关键词：

RhoGTPases; Rho-associated protein kinases; Gastric cancer; Motility; Metastasis; TUMOR-CELL INVASION; RHO-ASSOCIATED KINASE; AMEBOID-LIKE MOTILITY; HEPATOCELLULAR-CARCINOMA; UP-REGULATION; GTPASES; ROCK; INHIBITION; MIGRATION; ACTIVATION;

D O I：

10.3748/wjg.v20.i38.13756

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Gastric cancer is one of the most frequent and lethal malignancies worldwide because of high frequency of metastasis. Tumor cell motility and invasion play fundamental roles in cancer metastasis. Recent studies have revealed that the Rho/Rho-associated protein kinases (ROCK) pathway plays a critical role in the regulation of cancer cell motility and invasion. In addition, the Rho/ROCK pathway plays important roles in invasion and metastasis on the basis of its predominant function of cell cytoskeletal regulation in gastric cancer. According to the current understanding of tumor motility, there are two modes of tumor cell movement: mesenchymal and amoeboid. In addition, cancer cell movement can be interchangeable between the mesenchymal and amoeboid movements under certain conditions. Control of cell motility through the actin cytoskeleton creates the potential for regulating tumor cell metastasis. In this review we discuss Rho GTPases and ROCK signaling and describe the mechanisms of Rho/ROCK activity with regard to motility and metastasis in gastric cancer. In addition, we provide an insight of the therapeutic potential of targeting the Rho/ROCK pathway. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

引用

页码：13756 / 13766

页数：11

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