Polymeric Nanoarchitectures on Ti-Based Implants for Antibacterial Applications

被引：106

作者：

Zhang, Long ^{[1
]}

Ning, Chengyun ^{[2
]}

Zhou, Tian ^{[1
]}

Liu, Xiangmei ^{[1
]}

Yeung, K. W. K. ^{[3
]}

Zhang, Tianjin ^{[1
]}

Xu, Zushun ^{[1
]}

Wang, Xianbao ^{[1
]}

Wu, Shuilin ^{[1
]}

Chu, Paul K. ^{[4
]}

机构：

[1] Hubei Univ, Fac Mat Sci & Engn, Hubei Prov Key Lab Ind Biotechnol,Hubei Collabora, Minist Educ,Key Lab Green Preparat & Applicat Fun, Wuhan, Peoples R China

[2] S China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510641, Guangdong, Peoples R China

[3] Univ Hong Kong, Li Ka Shing Fac Med, Dept Orthopaed & Traumatol, Div Spine Surg, Hong Kong, Hong Kong, Peoples R China

[4] City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2014年 / 6卷 / 20期

关键词：

polymeric nanoarchitecture; antibacterial properties; biomedical implants; titanium; surface modification; FUNCTIONALIZED TITANIUM SURFACES; REDUCING BACTERIAL ADHESION; AMMONIUM-CHLORIDE CHITOSAN; ANTIMICROBIAL PEPTIDES; CONTROLLED-RELEASE; IN-VITRO; STAPHYLOCOCCUS-AUREUS; BIOFILM FORMATION; CARBOXYMETHYL CHITOSAN; PSEUDOMONAS-AERUGINOSA;

D O I：

10.1021/am5045604

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Because of the excellent mechanical properties and good biocompatibility, titanium-based metals are widely used in hard tissue repair, especially load-bearing orthopedic applications. However, bacterial infection and complication during and after surgery often causes failure of the metallic implants. To endow titanium-based implants with antibacterial properties, surface modification is one of the effective strategies. Possessing the unique organic structure composed of molecular and functional groups resembling those of natural organisms, functionalized polymeric nanoarchitectures enhance not only the antibacterial performance but also other biological functions that are difficult to accomplish on many conventional bioinert metallic implants. In this review, recent advance in functionalized polymeric nanoarchitectures and the associated antimicrobial mechanisms are reviewed.

引用

页码：17323 / 17345

页数：23

共 192 条

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