Signalling, cell cycle and pluripotency in embryonic stem cells

被引：577

作者：

Burdon, T ^{[1
]}

Smith, A

Savatier, P

机构：

[1] Roslin Inst, Dept Gene Express & Dev, Roslin EH25 9PS, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Genome Res, Edinburgh EH9 3JQ, Midlothian, Scotland

[3] Ecole Normale Super Lyon, Lab Biol Mol & Cellulaire, CNRS, UMR 5665,INRA, F-69364 Lyon 07, France

来源：

TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 09期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0962-8924(02)02352-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pluripotent mouse embryonic stem (ES) cells can be expanded in large numbers in vitro owing to a process of symmetrical self-renewal. Self-renewal entails proliferation with a concomitant suppression of differentiation. Here we describe how the cytokine leukaemia inhibitory factor (LIF) sustains self-renewal through activation of the transcription factor STAT3, and how two other signals - extracellular-signal-related kinase (ERK) and phosphatidylinositol-3-OH kinase (PI3K) - can influence differentiation and propagation, respectively. We relate these observations to the unusual cell-cycle properties of ES cells and speculate on the role of the cell cycle in maintaining pluripotency.

引用

页码：432 / 438

页数：7