The role of microRNAs in normal hematopoiesis and hematopoietic malignancies

被引：85

作者：

Kluiver, J.

Kroesen, B. -J.

Poppema, S.

van den Berg, A.

机构：

[1] Univ Groningen, Med Ctr, Dept Pathol & Lab Med, Sect Pathol, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Med Ctr, Dept Pathol & Lab Med, Sect Med Biol, Groningen, Netherlands

来源：

LEUKEMIA | 2006年 / 20卷 / 11期

关键词：

microRNA; hematopoiesis; lymphoma;

D O I：

10.1038/sj.leu.2404387

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the past few years, it has become evident that microRNAs ( miRNAs) play an important regulatory role in various biological processes. Much effort has been put into the elucidation of their biogenesis, and this has led to the general concept that a number of key regulators are shared with the processing machinery of small interfering RNAs. Despite the recognition that several miRNAs play crucial roles in normal development and in diseases, little is known about their exact molecular function and the identity of their target genes. In this review, we report on the biological relevance of miRNAs for the differentiation of normal hematopoietic cells and on the contribution of deregulated miRNA expression in their malignant counterparts.

引用

页码：1931 / 1936

页数：6

共 56 条

[1] Prediction and validation of microRNAs and their targets [J].

Bentwich, I .

FEBS LETTERS, 2005, 579 (26) :5904-5910

[2]

Borkhardt A, 2006, NEW ENGL J MED, V354, P524

[3]

Bullrich F, 2001, CANCER RES, V61, P6640

[4] Sizing up miRNAs as cancer genes [J].

Caldas, C ;

Brenton, JD .

NATURE MEDICINE, 2005, 11 (07) :712-714

[5] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[6] Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J].

Calin, GA ;

Sevignani, C ;

Dan Dumitru, C ;

Hyslop, T ;

Noch, E ;

Yendamuri, S ;

Shimizu, M ;

Rattan, S ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2999-3004

[7] A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia [J].

Calin, GA ;

Ferracin, M ;

Cimmino, A ;

Di Leva, G ;

Shimizu, M ;

Wojcik, SE ;

Iorio, MV ;

Visone, R ;

Sever, NI ;

Fabbri, M ;

Iuliano, R ;

Palumbo, T ;

Pichiorri, F ;

Roldo, C ;

Garzon, R ;

Sevignani, C ;

Rassenti, L ;

Alder, H ;

Volinia, S ;

Liu, CG ;

Kipps, TJ ;

Negrini, M ;

Croce, CM .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) :1793-1801

[8] MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias [J].

Calin, GA ;

Liu, CG ;

Sevignani, C ;

Ferracin, M ;

Felli, N ;

Dumitru, CD ;

Shimizu, M ;

Cimmino, A ;

Zupo, S ;

Dono, M ;

Dell'Aquila, ML ;

Alder, H ;

Rassenti, L ;

Kipps, TJ ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11755-11760

[9] Real-time quantification of microRNAs by stem-loop RT-PCR [J].

Chen, CF ;

Ridzon, DA ;

Broomer, AJ ;

Zhou, ZH ;

Lee, DH ;

Nguyen, JT ;

Barbisin, M ;

Xu, NL ;

Mahuvakar, VR ;

Andersen, MR ;

Lao, KQ ;

Livak, KJ ;

Guegler, KJ .

NUCLEIC ACIDS RESEARCH, 2005, 33 (20) :e179.1-e179.9

[10] MicroRNAs as oncogenes and tumor suppressors [J].

Chen, CZ .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) :1768-1771

← 1 2 3 4 5 6 →