Wnt6 marks sites of epithelial transformations in the chick embryo

被引：80

作者：

Schubert, FR

Mootoosamy, RC

Walters, EH

Graham, A

Tumiotto, L

Münsterberg, AE

Lumsden, A

Dietrich, S

机构：

[1] Kings Coll London, Dept Craniofacial Dev, London SE1 9RT, England

[2] Kings Coll London, MRC, Ctr Dev Neurobiol, London SE1 1UL, England

[3] Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 114卷 / 1-2期

基金：

英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

vertebrates; chick; central nervous system; neural fold; neural crest; ectoderm; heart; ear; branchial arches; somite patterning; neurulation; epithelial-mesenchymal transformation;

D O I：

10.1016/S0925-4773(02)00039-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In a screen for Wnt genes executing the patterning function of the vertebrate surface ectoderm, we have isolated a novel chick Wnt gene, chick Wnt6. This gene encodes the first pan-epidermal Writ signalling molecule. Further sites of expression are the boundary of the early neural plate and surface ectoderm, the roof of mesencephalon, pretectum and dorsal thalamus, the differentiating heart, and the otic vesicle. The precise sites of Wnt6 expression coincide with crucial changes in tissue architecture, namely epithelial remodelling and epithelial-mesenchymal transformation (EMT). Moreover, the expression of Wnt6 is closely associated with areas of Bmp signalling. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 148

页数：6

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