Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair

被引：140

作者：

Blesch, A

Lu, P

Tuszynski, MH

机构：

[1] Univ Calif San Diego, Dept Neurosci 0626, La Jolla, CA 92093 USA

[2] Vet Adm Med Ctr, San Diego, CA 92161 USA

来源：

BRAIN RESEARCH BULLETIN | 2002年 / 57卷 / 06期

关键词：

regeneration; spinal cord injury; transplantation; neurotrophin;

D O I：

10.1016/S0361-9230(01)00774-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several experimental strategies have been employed to minimize tissue damage and to enhance axonal growth and regeneration after spinal cord injury. The transplantation of suitable cell types to provide an axonal growth substrate and the application of growth factors have been shown to augment morphological and sometimes functional recovery. In this review we discuss the use of neural stem cell transplants and neurotrophic factor delivery by gene therapy to improve axonal regeneration in animal models of spinal cord injury. (C) 2002 Elsevier Science Inc.

引用

收藏

页码：833 / 838

页数：6

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