Protein-mediated fatty acid uptake: Novel insights from in vivo models

被引:176
作者
Doege, Holger [1 ]
Stahl, Andreas
机构
[1] Palo Alto Med Fdn Res Inst, Palo Alto, CA USA
[2] Stanford Univ, Sch Med, Div GI Hepatol, Stanford, CA 94305 USA
关键词
D O I
10.1152/physiol.00014.2006
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Long-chain fatty acids are both important metabolites as well as signaling molecules. Fatty acid transport proteins are key mediators of cellular fatty acid uptake and recent transgenic and knockout animal models have provided new insights into their contribution to energy homeostasis and to pathological processes, including obesity and insulin desensitization.
引用
收藏
页码:259 / 268
页数:10
相关论文
共 99 条
[51]   Hypothalamic sensing of fatty acids [J].
Lam, TKT ;
Schwartz, GJ ;
Rossetti, L .
NATURE NEUROSCIENCE, 2005, 8 (05) :579-584
[52]   Membrane topology of the murine fatty acid transport protein 1 [J].
Lewis, SE ;
Listenberger, LL ;
Ory, DS ;
Schaffer, JE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (40) :37042-37050
[53]  
Li Liwu, 2004, Curr Drug Targets Inflamm Allergy, V3, P81, DOI 10.2174/1568010043483863
[54]  
Lichtenstein AH, 1998, NUTR REV, V56, pS3
[55]   REGULATION OF FATTY-ACID OXIDATION IN THE MAMMALIAN HEART IN HEALTH AND DISEASE [J].
LOPASCHUK, GD ;
BELKE, DD ;
GAMBLE, J ;
ITOI, T ;
SCHONEKESS, BO .
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1994, 1213 (03) :263-276
[56]   Nonalcoholic fatty liver disease - A feature of the metabolic syndrome [J].
Marchesini, G ;
Brizi, M ;
Bianchi, G ;
Tomassetti, S ;
Bugianesi, E ;
Lenzi, M ;
McCullough, AJ ;
Natale, S ;
Forlani, G ;
Melchionda, N .
DIABETES, 2001, 50 (08) :1844-1850
[57]   A transgenic model of visceral obesity and the metabolic syndrome [J].
Masuzaki, H ;
Paterson, J ;
Shinyama, H ;
Morton, NM ;
Mullins, JJ ;
Seckl, JR ;
Flier, JS .
SCIENCE, 2001, 294 (5549) :2166-2170
[58]   Lack of association between certain candidate gene polymorphisms and the metabolic syndrome [J].
Meirhaeghe, A ;
Cottel, D ;
Amouyel, P ;
Dallongeville, J .
MOLECULAR GENETICS AND METABOLISM, 2005, 86 (1-2) :293-299
[59]   Intronic polymorphism in the fatty acid transport protein 1 gene is associated with increased plasma triglyceride levels in a French population [J].
Meirhaeghe, A ;
Martin, G ;
Nemoto, M ;
Deeb, S ;
Cottel, D ;
Auwerx, J ;
Amouyel, P ;
Helbecque, N .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (05) :1330-1334
[60]   BIOCHEMICAL AND GENETIC ASPECTS OF MENTAL RETARDATION [J].
MENKES, JH ;
MIGEON, BR .
ANNUAL REVIEW OF MEDICINE, 1966, 17 :407-+