Diastereo- and regioselective palladium-indium bimetallic cyclisation-Barbier-type allylation cascades

被引：32

作者：

Cooper, IR

Grigg, R ^{[1
]}

MacLachlan, WS

Sridharan, V

Thornton-Pett, M

机构：

[1] Univ Leeds, Sch Chem, MIDAS Ctr, Leeds LS2 9JT, W Yorkshire, England

[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(02)02428-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new diastereo-and regioselective Pd In bimetallic cascade process which assembles three contiguous chiral centres is described. Pd(0)-catalysed cyclisation of aryl iodides onto proximate 1,3-dienes generates pi-allylpalladium(II) species, transmetallation with indium and subsequent Barbier-type addition to aldehydes affords heterocyclic homoallylic alcohols. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：403 / 405

页数：3

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