In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones

被引：56

作者：

Coenye, Tom

Honraet, Kris

Rigole, Petra

Jimenez, Pol Nadal

Nelis, Hans J.

机构：

[1] Univ Ghent, Lab Farmaceut Microbiol, B-9000 Ghent, Belgium

[2] Oystershell NV, Drongen, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期

关键词：

D O I：

10.1128/AAC.00999-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species, the latter do not underlie the observed effect. Our results suggest that AQs inhibit S. mutans biofilm formation by causing membrane perturbation.

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收藏

页码：1541 / 1544

页数：4

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