Squamocin-O1 and squamocin-O2, new adjacent bis-tetrahydrofuran acetogenins from the seeds of Annona squamosa

被引：29

作者：

Araya, H

Sahai, M

Singh, S

Singh, AK

Yoshida, M

Hara, N

Fujimoto, Y ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem & Mat Sci, Meguro Ku, Tokyo 1528551, Japan

[2] Natl Inst Agroenvironm Sci, Tsukuba, Ibaraki 3058604, Japan

[3] Banaras Hindu Univ, IMS, Dept Med Chem, Varanasi 221005, Uttar Pradesh, India

[4] Natl Canc Ctr, Res Inst, Div Pharmacol, Chuo Ku, Tokyo 1040045, Japan

来源：

PHYTOCHEMISTRY | 2002年 / 61卷 / 08期

关键词：

Annona squamosa; Annonaceae; bis-tetrahydrofuran acetogenin; squamocin;

D O I：

10.1016/S0031-9422(02)00351-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two bis-tetrahydrofuran acetogenins, squamocin-O-1 (1) and squamocin-O-2 (2), were isolated from a MeOH extract of seeds of Annona squamosa L. Their structures were determined by spectral means including precursor-ion scanning mass spectral analysis for their aminal derivatives. The configurations at the oxymethine chiral centers were assigned as 12R,15R,16R,19R,20R,23R,24S,28S,36S for 1 and 12S,15R,16R,19R,20R,23R,24S,28S,36S for 2, based on H-1 NMR analysis of their Mosher's ester derivatives and CD data. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：999 / 1004

页数：6

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