Bone collagen cross-links: an efficient one-pot synthesis of (+)-pyridinoline and (+)-deoxypyridinoline

被引：25

作者：

Adamczyk, M ^{[1
]}

Johnson, DD ^{[1
]}

Reddy, RE ^{[1
]}

机构：

[1] Abbott Labs, Div Diagnost, Dept Chem, Abbott Pk, IL 60064 USA

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(00)00195-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A one-pot reaction of (2S, 5R)-(-)-tert-butyl-[(2-tert-butoxycarbonyl)amino]-5-hydroxy-6-amino-hexanoate 2b or (S)-(-)-tert-butyl-[(2-tert-butoxycarbonyl)amino]-6-aminohexanoate 2c with (S)-(-)-tert-butyl-6-bromo-[bis-(2-tert-butoxycarbonyl)amino]-5-oxohexanoate 5 in the presence of K2CO3 in MeCN-MeOH followed by hydrolysis gave bone collagen cross-links, (+)-Pyd 1b or (+)-Dpd 1c, in 42-48% yield, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2289 / 2298

页数：10

共 37 条

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