Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses correlate with control of acute HIV-1 infection in macaques

被引:42
作者
Kent, SJ
Woodward, A
Zhao, A
机构
[1] AIDS Pathogenesis Research Unit, Macfarlane Burnet Ctr. for Med. Res., Fairfield
[2] AIDS Pathogenesis Research Unit, Macfarlane Burnet Ctr. for Med. Res., Fairfield, Vic. 3078
关键词
D O I
10.1086/514112
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Macaca nemestrina efficiently control acute human immunodeficiency virus type 1 (HIV-I) infection, The roles of helper (Th) and cytotoxic (CTL) T cells in controlling acute HIV-1 infection in both peripheral blood and lymph node mononuclear cells (PBMC and LNMC) were assessed in this model, Th and CTL responses to HIV-1 were detected within 2 weeks following HIV-1 infection, and CTL responses to HIV-1 antigens peaked at 4 weeks after infection (>100 HIV-specific CTL/10(6) PBMC), coincident with reductions of HIV-1 RNA and DNA levels in peripheral blood, HIV-l-specific Th and CTL were present in LNMC 6 weeks after infection, Although HIV-1 antibodies were detected 2 weeks after infection, maximal HIV-1 antibody responses were not generated until > 13 weeks after inoculation, Thus, T cell responses temporally correlate with control of HIV-1 in macaques. The induction of a brisk HIV-l-specific CTL response may have been facilitated by a persistent Th response.
引用
收藏
页码:1188 / 1197
页数:10
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