Metrics to 'green' chemistry - which are the best?

被引:658
作者
Constable, DJC
Curzons, AD
Cunningham, VL
机构
[1] GlaxoSmithKline, King Of Prussia, PA 19406 USA
[2] GlaxoSmithKline, Worthing BN14 8NQ, W Sussex, England
关键词
D O I
10.1039/b206169b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A considerable amount has been written about the use of metrics to drive business, government and communities towards more sustainable practices. A number of metrics have also been proposed over the past 5-10 years to make chemists aware of the need to change the methods used for chemical syntheses and chemical processes. This paper explores several metrics commonly used by chemists and compares and contrasts these metrics with a new metric known as reaction mass efficiency. The paper also uses an economic analysis of four commercial pharmaceutical processes to understand the relationship between metrics and the most important cost drivers in these processes.
引用
收藏
页码:521 / 527
页数:7
相关论文
共 9 条
  • [1] BENNETT M, 1999, SUSTAINABLE MEASURES
  • [2] Green chemistry measures for process research and development
    Constable, DJC
    Curzons, AD
    dos Santos, LMF
    Geen, GR
    Hannah, RE
    Hayler, JD
    Kitteringham, J
    McGuire, MA
    Richardson, JE
    Smith, P
    Webb, RL
    Yu, M
    [J]. GREEN CHEMISTRY, 2001, 3 (01) : 7 - 9
  • [3] So you think your process is green, how do you know? Using principles of sustainability to determine what is green - a corporate perspective
    Curzons, AD
    Constable, DJC
    Mortimer, DN
    Cunningham, VL
    [J]. GREEN CHEMISTRY, 2001, 3 (01) : 1 - 6
  • [4] *HAYM BUS PUBL, 1999, CORP ENV PERF 2000, V1
  • [5] Toward a 'reagent-free' synthesis - Tandem enzymatic and electrochemical methods for increased effective mass yield (EMY)
    Hudlicky, T
    Frey, DA
    Koroniak, L
    Claeboe, CD
    Brammer, LE
    [J]. GREEN CHEMISTRY, 1999, 1 (02) : 57 - 59
  • [6] *NAT AC ENG NAT RE, 1999, IND ENV PERF METR CH
  • [7] SHELDON RA, 1992, CHEM IND-LONDON, P903
  • [8] Sheldon RA, 1997, CHEM IND-LONDON, P12
  • [9] THE ATOM ECONOMY - A SEARCH FOR SYNTHETIC EFFICIENCY
    TROST, BM
    [J]. SCIENCE, 1991, 254 (5037) : 1471 - 1477