Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness

被引：133

作者：

Remst, Dennis F. G. ^{[1
]}

Davidson, Esmeralda N. Blaney ^{[1
]}

van der Kraan, Peter M. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Expt Rheumatol, NL-6525 GA Nijmegen, Netherlands

来源：

RHEUMATOLOGY | 2015年 / 54卷 / 11期

关键词：

synovium; fibrosis; osteoarthritis; TGF-beta; connective tissue growth factor; lysyl hydroxylase 2b; tissue inhibitor of metalloproteinase 1; A disintegrin and metalloproteinase domain 12; Hyaluronan; PGF(2 alpha); TISSUE GROWTH-FACTOR; LYSYL HYDROXYLASE 2B; PYRIDINOLINE CROSS-LINKS; TGF-BETA; UROTENSIN-II; RENAL FIBROSIS; CARTILAGE DEGRADATION; COLLAGEN-SYNTHESIS; SIGNALING PATHWAY; ALK5; INHIBITOR;

D O I：

10.1093/rheumatology/kev228

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Synovial fibrosis is often found in OA, contributing heavily to joint pain and joint stiffness, the main symptoms of OA. At this moment the underlying mechanism of OA-related synovial fibrosis is not known and there is no cure available. In this review we discuss factors that have been reported to be involved in synovial fibrosis. The aim of the study was to gain insight into how these factors contribute to the fibrotic process and to determine the best targets for therapy in synovial fibrosis. In this regard, the following factors are discussed: TGF-beta, connective tissue growth factor, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, tissue inhibitor of metalloproteinase 1, A disintegrin and metalloproteinase domain 12, urotensin-II, prostaglandin F-2 alpha and hyaluronan.

引用

页码：1954 / 1963

页数：10

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