Synthesis of 5-methylfuro[3,2-c]quinolin-4(5H)-one via palladium-catalysed cyclisation of N-(2-iodophenyl)-N-methyl-3-furamide

被引：21

作者：

Lindahl, Karl-Fredrik ^{[1
]}

Carroll, Anthony ^{[1
]}

Quinn, Ronald J. ^{[1
]}

Ripper, Justin A. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 42期

关键词：

furoquinolinones; palladium catalyst; palladium oxide;

D O I：

10.1016/j.tetlet.2006.08.032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of the furo[3,2-c]quinolin-4(5H) -one heterocycle has been developed using a palladium-catalysed cyclisation of N-(2-iodophenyl)-N-methyl-3-furamide. By varying the catalyst, base and solvent, the yield of the cyclisation was optimised. It was found that the use of palladium oxide with potassium acetate in N,N-dimethylacetamide (DMA) with a small amount of tetrabutylammonium chloride gave the highest yield of 5 -methylfuro [3,2-c]quinolin-4(5H) -one (9). (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7493 / 7495

页数：3

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