Influence of mutations in the mexR repressor gene on expression of the MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa

被引：121

作者：

Srikumar, R ^{[1
]}

Paul, CJ ^{[1
]}

Poole, K ^{[1
]}

机构：

[1] Queens Univ, Dept Microbiol & Immunol, Kingston, ON K7L 3N6, Canada

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 05期

关键词：

D O I：

10.1128/JB.182.5.1410-1414.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several nalB-type multidrug-resistant mutants of Pseudomonas aeruginosa overexpressed MexAB-OprM and carried mutations in the total regulatory gene, mexR. Others, dubbed nalC types, carried mutations elsewhere and overexpressed MexAB-OprM less extensively than the nalB strains. Available evidence showed that MexR acted solely as repressor. Disruption of the mexR gene at various places suggested that the 5' end of mexR may be a part of the mexAB-oprM promoter.

引用

页码：1410 / 1414

页数：5

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