Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa

被引：214

作者：

Mine, T

Morita, Y

Kataoka, A

Mizushima, T

Tsuchiya, T ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Dept Microbiol, Okayama 7008530, Japan

[2] Okayama Univ, Ctr Gene Res, Okayama 7008530, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 02期

关键词：

D O I：

10.1128/AAC.43.2.415

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two new genes (mexXY) similar to mexAB, mexCD, and mexEF and mediating multidrug resistance were cloned from the chromosome of Pseudomonas aeruginosa. Elevated ethidium extrusion was observed with Escherichia coli cells harboring the plasmid carrying mexXY. This MexXY system confers higher resistance to fluoroquinolones than the MexAB and MexCD systems, and E. coli TolC or P. aeruginosa OprM is necessary for the function of the MexXY system.

引用

页码：415 / 417

页数：3

共 26 条

[1] ISOLATION OF HIGH MOLECULAR WEIGHT DNA FROM HEMOPHILUS INFLUENZAE
BERNS, KI
THOMAS, CA
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1965, 11 (03) : 476 - &
[2] PROTON MOTIVE FORCE-DRIVEN AND ATP-DEPENDENT DRUG EXTRUSION SYSTEMS IN MULTIDRUG-RESISTANT LACTOCOCCUS-LACTIS
BOLHUIS, H
MOLENAAR, D
POELARENDS, G
VANVEEN, HW
POOLMAN, B
DRIESSEN, AJM
KONINGS, WN
[J]. JOURNAL OF BACTERIOLOGY, 1994, 176 (22) : 6957 - 6964
[3] ANALYSIS OF MEMBRANE AND SURFACE PROTEIN SEQUENCES WITH THE HYDROPHOBIC MOMENT PLOT
EISENBERG, D
SCHWARZ, E
KOMAROMY, M
WALL, R
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1984, 179 (01) : 125 - 142
[4] Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli
Fralick, JA
[J]. JOURNAL OF BACTERIOLOGY, 1996, 178 (19) : 5803 - 5805
[5] STUDIES ON TRANSFORMATION OF ESCHERICHIA-COLI WITH PLASMIDS
HANAHAN, D
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1983, 166 (04) : 557 - 580
[6] Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa
Kohler, T
MicheaHamzehpour, M
Henze, U
Gotoh, N
Curty, LK
Pechere, JC
[J]. MOLECULAR MICROBIOLOGY, 1997, 23 (02) : 345 - 354
[7] TRANSDUCTION OF LINKED GENETIC CHARACTERS OF THE HOST BY BACTERIOPHAGE-PL
LENNOX, ES
[J]. VIROLOGY, 1955, 1 (02) : 190 - 206
[8] ROLE OF MEXA-MEXB-OPRM IN ANTIBIOTIC EFFLUX IN PSEUDOMONAS-AERUGINOSA
LI, XZ
NIKAIDO, H
POOLE, K
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (09) : 1948 - 1953
[9] ROLE OF EFFLUX PUMP(S) IN INTRINSIC RESISTANCE OF PSEUDOMONAS-AERUGINOSA - RESISTANCE TO TETRACYCLINE, CHLORAMPHENICOL, AND NORFLOXACIN
LI, XZ
LIVERMORE, DM
NIKAIDO, H
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (08) : 1732 - 1741
[10] MOLECULAR-CLONING AND CHARACTERIZATION OF ACRA AND ACRE GENES OF ESCHERICHIA-COLI
MA, D
COOK, DN
ALBERTI, M
PON, NG
NIKAIDO, H
HEARST, JE
[J]. JOURNAL OF BACTERIOLOGY, 1993, 175 (19) : 6299 - 6313

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