The role of CD1 molecules in immune responses to infection

被引：25

作者：

Maher, JK

Kronenberg, M

机构：

[1] UNIV CALIF LOS ANGELES,INST MOL BIOL,DEPT IMMUNOL,LOS ANGELES,CA 90095

[2] LA JOLLA INST ALLERGY & IMMUNOL,DIV DEV IMMUNOL,SCI CTR 10355,SAN DIEGO,CA 92121

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(97)80095-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent work an CD1 molecules has demonstrated that human CD1b and a lipoglycan from mycobacteria that CD1b presents colocalize to late endosomes. Presentation of this lipoglycan by CD1b requires antigen uptake via the mannose receptor. CD8(+) CD1-restricted T cells can decrease the load of intracellular mycobacteria by granule release. TCR-transgenic and CD1-deficient mice have provided insights into the role of CD1 in the T helper responses required for the clearance of some microorganisms.

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页码：456 / 461

页数：6

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