Gymnastatins F-H, cytostatic metabolites from the sponge-derived fungus Gymnascella dankaliensis

被引：69

作者：

Amagata, Taro ^{[1
]}

Minoura, Katsuhiko ^{[1
]}

Numata, Atsushi ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Osaka 5691094, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 10期

关键词：

D O I：

10.1021/np0600189

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Gymnastatins F - H (2-4) and gymnamide ( 5) have been isolated from the mycelial MeOH extract of the Halichondria sponge-derived fungus Gymnascella dankaliensis. Their stereostructures have been established on the basis of spectroscopic analyses using 1D and 2D NMR techniques. The stereochemistry of gymnastatin H ( 4) was determined by its synthesis. Among these compounds, gymnastatins F ( 2) and G ( 3) possess a unique bicyclo[3.3.1] nonane ring as natural products, and they were found to exhibit potent growth inhibition against the P388 cancer cell line.

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页码：1384 / 1388

页数：5

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