Use of the Hayling task to measure inhibition of prepotent responses in normal aging and Alzheimer's disease

被引:112
作者
Belleville, Sylvie [1 ]
Rouleau, Nancle
Van der Linden, Martial
机构
[1] Univ Montreal, Res Ctr, Inst Geriatr, Montreal, PQ, Canada
[2] Univ Montreal, Dept Psychol, Montreal, PQ, Canada
[3] Univ Laval, Ecole Psychol, Quebec City, PQ, Canada
[4] Univ Laval Robert Giffard, Quebec City, PQ, Canada
[5] Univ Geneva, Fac Psychol & Sci Educ, Unite Psychopathol & Neuropsychol Cognit, Geneva, Switzerland
基金
加拿大健康研究院;
关键词
executive functions; inhibition; Alzheimer's disease; Hayling test;
D O I
10.1016/j.bandc.2006.04.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This study measures the effect of Alzheimer's disease (AD) and normal aging on the inhibition of prepotent responses. AD patients, normal aged controls, and young subjects were tested with the Hayling task, which measures the ability to inhibit a semantically constrained response, and with the Stroop procedure. AD patients showed a severe deficit in both error rates and response time on the Hayling task. Inhibition was also impaired on the Stroop procedure, both when using raw performance and when using an inhibition score that controlled for reading and naming speed. Normal aged participants showed modest impairment relative to young controls on both tests. Examination of individual performance in AD patients indicated that the impairment was found in most patients on the Hayling test but in only a subgroup of patients on the Stroop test. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:113 / 119
页数:7
相关论文
共 33 条
[31]   BEHAVIORAL GOALS DETERMINE INHIBITORY MECHANISMS OF SELECTIVE ATTENTION [J].
TIPPER, SP ;
WEAVER, B ;
HOUGHTON, G .
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION A-HUMAN EXPERIMENTAL PSYCHOLOGY, 1994, 47 (04) :809-840
[32]   A STANDARDIZED MEMORY SCALE FOR CLINICAL USE [J].
Wechsler, David .
JOURNAL OF PSYCHOLOGY, 1945, 19 (01) :87-95
[33]   An application of prefrontal cortex function theory to cognitive aging [J].
West, RL .
PSYCHOLOGICAL BULLETIN, 1996, 120 (02) :272-292