Current Treatment of In-Stent Restenosis

被引：455

作者：

Alfonso, Fernando ^{[1
]}

Byrne, Robert A. ^{[2
,3
]}

Rivero, Fernando ^{[1
]}

Kastrati, Adnan ^{[2
,3
]}

机构：

[1] Hosp Univ LA Princesa Madrid, Dept Cardiac, Madrid, Spain

[2] Tech Univ Munich, Deutsch Herzzentrum, D-80290 Munich, Germany

[3] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2014年 / 63卷 / 24期

关键词：

bare-metal stents; drug-coated balloons; drug-eluting stents; in-stent restenosis; intravascular ultrasound; neoatherosclerosis; optical coherence tomography; DRUG-ELUTING STENT; PACLITAXEL-COATED BALLOON; BARE-METAL STENTS; GAMMA-RADIATION THERAPY; ANGIOGRAPHIC FOLLOW-UP; LONG-TERM OUTCOMES; ROTATIONAL ATHERECTOMY; RANDOMIZED-TRIAL; CUTTING BALLOON; ISAR-DESIRE;

D O I：

10.1016/j.jacc.2014.02.545

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Management of patients with in-stent restenosis (ISR) remains an important clinical problem. Although drug-eluting stents (DES) have drastically reduced the incidence of ISR, treatment of DES-ISR is particularly challenging. ISR mainly results from aggressive neointimal proliferation, but recent data also suggest that neoatherosclerosis may play an important pathophysiological role. Intracoronary imaging provides unique insights to unravel the underlying substrate of ISR and may be used to guide repeated interventions. In this paper, we systematically reviewed clinical trial data with currently available therapeutic modalities, including DES and drug-coated balloons, in patients presenting with ISR within bare-metal stents or DES. (c) 2014 by the American College of Cardiology Foundation

引用

页码：2659 / 2673

页数：15

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